SEMIZ AYOLLARDA PREEKLAMPSIYA XAVFINI ERTA ANIQLASH UCHUN HOMILADORLIKNING BIRINCHI UCH OYLIGIDA L/A (LEPTIN/ADIPONEKTIN) NISBATINING BASHORAT QILISH QIYMATI
##semicolon##
preeklampsiyaAbstrak
Maqsad - semizligi bor ayollarda homiladorlikning birinchi uch oyligida L/A (leptin/adiponektin) indeksining tashxisiy va prognostik ahamiyatini baholash orqali preeklampsiyani erta bashorat qilish. Prospektiv tadqiqotga 190 nafar homilador ayol (130 nafari TVI ≥ 30 kg/m² va 60 nafari normal vaznli) jalb qilindi. Qon zardobidagi leptin va adiponektin miqdori 11-13 haftalikda aniqlandi. L/A ko‘rsatkichining 5 dan yuqori bo‘lishi preeklampsiyani 88% sezuvchanlik va 81% o‘ziga xoslik bilan bashorat qildi. Iqtisodiy tahlil natijalariga ko‘ra, atsetilsalitsil kislotasi bilan profilaktika qilish skriningni 14 barobar samarali qilishini ko‘rsatdi.
##submission.citations##
[1] Taylor B.D., Ness R.B., Olsen J. и др. Serum leptin measured in early pregnancy is higher in women with preeclampsia compared with normotensive pregnant women // Hypertension. 2015. Т. 65. № 3. С. 594 599.
[2] Elgazzaz M., Brawley A., Moronge D., Faulkner J.L. Emerging role of leptin in vascular and placental dysfunction in preeclampsia // Arterioscler Thromb Vasc Biol. 2025. Т. 45. № 5. С. 789 803.
[3] de Knegt V.E., Hedley P.L., Eltvedt A.K. и др. First trimester maternal serum adiponectin/leptin ratio in pre eclampsia and fetal growth // Life. 2023. Т. 13. № 1. С. 130.
[4] Park S., Lee H.J., Oh S.Y. и др. Leptin and adiponectin as markers for preeclampsia in obese pregnant women // Pregnancy Hypertens. 2019. Т. 15. С. 78 83.
[5] Hao S., You J., Chen L. и др. Changes in pregnancy related serum biomarkers early in gestation are associated with later development of preeclampsia // PLoS One. 2020. Т. 15. № 3. С. e0230000.
[6] Miettinen K.S., Villa P.M., Puttonen H. и др. Maternal adiponectin and leptin profiles among obese pregnant women with preeclampsia // Eur Rev Med Pharmacol Sci. 2024. Т. 28. С. 3922 3933.
[7] Maher G.M., Coffey M., Khashan A.S. и др. Low serum adiponectin and high leptin in hypertensive disorders of pregnancy: a cohort study // Int J Womens Health. 2025. Т. 17. С. 425 433.
[8] Kuc S., van Rijn B.B., Wortelboer E.J. и др. Serum adiponectin and leptin in relation to risk for preeclampsia // Metabolism. 2011. Т. 60. № 5. С. 703 708.
[9] Lauridsen J.H., Christoffersen M., Andersgaard A.B. и др. Adiponectin as a potential biomarker for pregnancy disorders // Int J Mol Sci. 2021. Т. 22. № 3. С. 1326.
[10] Briffa J.F., Umber B.S., Campbell F.M. и др. Mid gestation leptin infusion induces characteristics of clinical preeclampsia in mice // Hypertension. 2022. Т. 79. С. 1182 1191.
[11] Halari C.D., Osazuwa H., Ahmed M. и др. The role of serum adipokine levels in preeclampsia: a systematic review and meta analysis // Metabolism. 2020. Т. 107. С. 154213.
[12] Myers J.E., Kenny L.C., McCowan L.M.E. и др. Early pregnancy systolic blood pressure patterns and risk of preeclampsia // J Am Heart Assoc. 2023. Т. 12. С. e031068.
[13] Taal H.R., Steegers E.A., Hofman A. и др. Maternal adipokines and placental function in hypertensive disorders of pregnancy // Placenta. 2024. Т. 137. С. 98 107.
[14] Venkateshwar A., Kumar S., Rao K. и др. Early cost effectiveness analysis of screening for preeclampsia in nulliparous women // PLoS One. 2022. Т. 17. № 4. С. e0267313.
[15] El Sheikh M., Al Hakeem M.M., Abdalla H. и др. Maternal serum leptin, adiponectin and resistin in pre eclampsia and normal pregnancy // Clin Endocrinol. 2021. Т. 75. С. 2 11.
