ОСОБЕННОСТИ ГЕНЕТИЧЕСКОГО ПОЛИМОРФИЗМА ГЕНОВ PPARG, COMT И CAT В ПАТОГЕНЕЗЕ ПРИВЫЧНОГО НЕВЫНАШИВАНИЕМ БЕРЕМЕННОСТИ: СИСТЕМАТИЧЕСКИЙ ОБЗОР
Ключевые слова:
odatiy xomila tushishi,, trombofiliya,, PPARG,, COMT,, CAT.Аннотация
Odatiy (retsidivlovchi) homila tushishi reproduktiv tibbiyotdagi eng jiddiy muammolardan biri boʼlib kelmoqda. Аniqlangan sabablar (embrionning xromosoma anomaliyalari, anatomik omillar, antifosfolipid sindromi va boshqalar) bilan bir qatorda ona, ota va homilaning genetik polimorfizmlariga , shu jumladan qonning qotishiga, immunoregulyatsiyaga, folatlar metabolizmiga va antioksidant himoyasiga masʼul genlardagi variantlarga ham koʼproq eʼtibor qaratilmoqda. Maqolada turli klasli genetik markerlerning erta takroriy homila yoʼqotishlari xavfiga taʼsiri boʼyicha zamonaviy maʼlumotlar tizimli ravishda koʼrib chiqiladi, tashxis qoʼyish yondashuvlari va klinik tavsiyalar muhokama qilinadi, shuningdek kelgusidagi tadqiqotlar uchun asosiy yoʼnalishlar belgilab oʼtilgan. Аsosiy xulosalar: homilaning xromosoma anomaliyalari va ota-onaning restrukturizatsiyalari — isbotlangan omil; polimorfizmlar bilan bogʼliq assotsiatsiyalar (trombofiliya, MTHFR, immun va antioksidant genlar, PPARG/COMT, miRNA) alohida tadqiqotlar va meta-tahlillarda aniqlangan, ammo umumiy holda natijalar turlicha va koʼpchilik markerler boʼyicha hozircha rutin klinik verifikatsiya va maqsadli terapiya uchun yetarli dalillar mavjud emas.
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